CPCM Publications



Dalin S, Grauman-Boss B, Lauffenburger DA, Hemann MT. 2022. Collateral responses to classical cytotoxic chemotherapies are heterogeneous and sensitivities are sparse. Sci Rep 12:5453.

Datta R, Sivanand S, Lau AN, Florek LV, Barbeau AM, Wyckoff J, Skala MC, Vander Heiden MG. 2022. Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors. Sci Adv 8:eabg6383.

Davidson SM, Schmidt DR, Heyman JE, O’Brien JP, Liu AC, Israelsen WJ, Dayton TL, Sehgal R, Bronson RT, Freinkman E, Mak HH, Fanelli GN, Malstrom S, Bellinger G, Carracedo A, Pandolfi PP, Courtney KD, Jha A, DePinho RA, Horner JW, Thomas CJ, Cantley LC, Loda M, Vander Heiden MG. 2022. Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma. Cancer Res canres.CAN-21-2352-E.2021.

Ellson CD, Goretti Riça I, Kim JS, Huang Y-MM, Lim D, Mitra T, Hsu A, Wei EX, Barrett CD, Wahl M, Delbrück H, Heinemann U, Oschkinat H, Chang C-EA, Yaffe MB. 2022. An integrated pharmacological, structural, and genetic analysis of extracellular versus intracellular ROS production in neutrophils. J Mol Biol 167533.

Franklin R, Guo Y, He S, Chen M, Ji F, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco MA, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev RI, Murn J, Volk A, Cheloufi S. 2022. Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity. Nat Commun 13:2350.

Gouirand V, Gicquel T, Lien EC, Jaune-Pons E, Da Costa Q, Finetti P, Metay E, Duluc C, Mayers JR, Audebert S, Camoin L, Borge L, Rubis M, Leca J, Nigri J, Bertucci F, Dusetti N, Lucio Iovanna J, Tomasini R, Bidaut G, Guillaumond F, Vander Heiden MG, Vasseur S. 2022. Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression. EMBO J e110466.

Jaeger AM, Stopfer LE, Ahn R, Sanders EA, Sandel DA, Freed-Pastor WA, Rideout WM, Naranjo S, Fessenden T, Nguyen KB, Winter PS, Kohn RE, Westcott PMK, Schenkel JM, Shanahan S-L, Shalek AK, Spranger S, White FM, Jacks T. 2022. Deciphering the immunopeptidome in vivo reveals new tumour antigens. Nature.

Miettinen TP, Ly KS, Lam A, Manalis SR. 2022. Single-cell monitoring of dry mass and dry mass density reveals exocytosis of cellular dry contents in mitosis. eLife 11:e76664.

Netterfield TS, Ostheimer GJ, Tentner AR, Sorger PK, Janes KA, Lauffenburger DA, Yaffe MB. 2022. Biphasic JNK–Erk Signaling Separates Induction and Maintenance of Cell Senescence after DNA Damage. bioRxiv

Sriram G, Emmons TR, Milling LE, Irvine DJ, Yaffe MB. 2022. Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade. Mol Cell Oncol 9:2039038.


Abbott KL, Vander Heiden MG. 2021. The CAT-SIR is out of the bag: tumors prefer host rather than dietary nutrients. BMC Biol 19.

Bent EH, Millán-Barea LR, Zhuang I, Goulet DR, Fröse J, Hemann MT. 2021. Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy. Nat Commun 12:6218. 

Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, Chen IX, Naxerova K, Ng C, Westermark AM, Duquette M, Roberge S, Lindeman NI, Lyssiotis CA, Nielsen J, Housman DE, Duda DG, Brachtel E, Golub TR, Cantley LC, Asara JM, Davidson SM, Fukumura D, Dartois VA, Clish CB, Jain RK, Vander Heiden MG. 2021. Fatty acid synthesis is required for breast cancer brain metastasis. Nature Cancer 1–15. 

Francescone R, Vendramini-Costa DB, Franco-Barraza J, Wagner J, Muir A, Lau AN, Gabitova L, Pazina T, Gupta S, Luong T, Rollins D, Malik R, Thapa RJ, Restifo D, Zhou Y, Cai KQ, Hensley HH, Tan Y, Kruger WD, Devarajan K, Balachandran S, Klein-Szanto AJ, Wang H, El-Deiry WS, Vander Heiden MG, Peri S, Campbell KS, Astsaturov I, Cukierman E. 2021. Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression. Cancer Discov 11:446–479.

Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, Vander Heiden MG, Stephanopoulos G. 2021. Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells. FEBS J. 

Kelly JM, Ivatt PD, Evans MJ, Kroll JH, Hrdina AIH, Kohale IN, White FM, Engelward BP, Selin NE. 2021. Global Cancer Risk From Unregulated Polycyclic Aromatic Hydrocarbons. Geohealth 5:e2021GH000401.

Kohale IN, Burgenske DM, Mladek AC, Bakken KK, Kuang J, Boughey JC, Wang L, Carter JM, Haura EB, Goetz MP, Sarkaria JN, White FM. 2021. Quantitative analysis of tyrosine phosphorylation from FFPE tissues reveals patient-specific signaling networks. Cancer Res.

Leddy OK, White FM, Bryson BD. 2021. Leveraging Immunopeptidomics To Study and Combat Infectious Disease. mSystems 0:e00310-21.

Lien EC, Vander Heiden MG. 2021. Pancreatic β cells put the glutamine engine in reverse. Cell Metab 33:702–704.

Lien EC, Westermark AM, Zhang Y, Yuan C, Li Z, Lau AN, Sapp KM, Wolpin BM, Vander Heiden MG. 2021. Low glycaemic diets alter lipid metabolism to influence tumour growth. Nature 1–6.

Lopez BGC, Kohale IN, Du Z, Korsunsky I, Abdelmoula WM, Dai Y, Stopka SA, Gaglia G, Randall EC, Regan MS, Basu SS, Clark AR, Marin B-M, Mladek AC, Burgenske DM, Agar JN, Supko JG, Grossman SA, Nabors LB, Raychaudhuri S, Ligon KL, Wen PY, Alexander B, Lee EQ, Santagata S, Sarkaria J, White FM, Agar NYR. 2022. Multimodal platform for assessing drug distribution and response in clinical trials. Neuro Oncol 24:64–77.

Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferreira R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. 2021. Increased demand for NAD+ relative to ATP drives aerobic glycolysis. Mol Cell 81, 1–17.

Mueller HS, Fowler CE, Dalin S, Moiso E, Udomlumleart T, Garg S, Hemann MT, Lees JA. 2021. Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel. PNAS 118.

Pikman Y, Ocasio-Martinez N, Alexe G, Dimitrov B, Kitara S, Diehl FF, Robichaud AL, Conway AS, Ross L, Su A, Ling F, Qi J, Roti G, Lewis CA, Puissant A, Vander Heiden MG, Stegmaier K. 2021. Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy. Leukemia 1–13.

Schmidt DR, Patel R, Kirsch DG, Lewis CA, Heiden MGV, Locasale JW. 2021. Metabolomics in cancer research and emerging applications in clinical oncology. CA: A Cancer Journal for Clinicians.

Sriram G, Milling LE, Chen J-K, Kong YW, Joughin BA, Abraham W, Swartwout S, Handly ED, Irvine DJ, Yaffe MB. 2021. The injury response to DNA damage in live tumor cells promotes antitumor immunity. Sci Signal 14:eabc4764.

Stockslager MA, Malinowski S, Touat M, Yoon JC, Geduldig J, Mirza M, Kim AS, Wen PY, Chow K-H, Ligon KL, Manalis SR. 2021. Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models. Cell Rep 37:109788.

Stopfer LE, Conage-Pough JE, White FM. 2021. Quantitative consequences of protein carriers in immunopeptidomics and tyrosine phosphorylation MS2 analyses. Molecular & Cellular Proteomics.

Stopfer LE, Gajadhar AS, Patel B, Gallien S, Frederick DT, Boland GM, Sullivan RJ, White FM. 2021. Absolute quantification of tumor antigens using embedded MHC-I isotopologue calibrants. Proc Natl Acad Sci U S A 118:e2111173118. 

Stopfer LE, Flower CT, Gajadhar AS, Patel B, Gallien S, Lopez-Ferrer D, White FM. 2021. High-density, targeted monitoring of tyrosine phosphorylation reveals activated signaling networks in human tumors. Cancer Res.

Suarez-Lopez L, Kong YW, Sriram G, Patterson JC, Rosenberg S, Morandell S, Haigis KM, Yaffe MB. 2021. MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer. Front Immunol 11.

Sullivan MR, Darnell AM, Reilly MF, Kunchok T, Joesch-Cohen L, Rosenberg D, Ali A, Rees MG, Roth JA, Lewis CA, Vander Heiden MG. 2021. Methionine synthase is essential for cancer cell proliferation in physiological folate environments. Nat Metab 3:1500–1511.

Tian C, Huang Y, Clauser KR, Rickelt S, Lau AN, Carr SA, Vander Heiden MG, Hynes RO. 2021. Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells. Nature Communications 12:2328.


Alkan HF, Vesely PW, Hackl H, Foßelteder J, Schmidt DR, Vander Heiden MG, Pichler M, Hoefler G, Bogner-Strauss JG. 2020. Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis. Cancer Metab 8:26.

Bruno PM, Lu M, Dennis KA, Inam H, Moore CJ, Sheehe J, Elledge SJ, Hemann MT, Pritchard JR. 2020. The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning. PNAS 117: 4053–4060.

Chatterjee N, Whitman MA, Harris CA, Min SM, Jonas O, Lien EC, Luengo A, Vander Heiden MG, Hong J, Zhou P, Hemann MT, Walker GC. 2020. REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. Proc Natl Acad Sci USA 202016064.

Chen A, Koehler AN. 2020. Transcription factor inhibition: Lessons learned and emerging targets. Trends in Molecular Medicine 26: P508-518.

Francescone R, Barbosa Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A, Lau AN, Gabitova L, Pazina T, Gupta S, Luong T, Rollins D, Malik R, Thapa RJ, Restifo D, Zhou Y, Cai KQ, Hensley HH, Tan Y, Kruger WD, Devarajan K, Balachandran S, Klein-Szanto AJ, Wang H, El-Deiry WS, Vander Heiden MG, Peri S, Campbell KS, Astsaturov I, Cukierman E. 2020. Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression. Cancer Discov CD-20-0775.

Kang JH, Katsikis G, Li Z, Sapp KM, Stockslager MA, Lim D, Vander Heiden MG, Yaffe MB, Manalis SR, Miettinen TP. 2020. Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division. Nat Commun 11:4983.

Kong YW, Dreaden EC, Morandell S, Zhou W, Dhara SS, Sriram G, Lam FC, Patterson JC, Quadir M, Dinh A, Shopsowitz KE, Varmeh S, Yilmaz ÖH, Lippard SJ, Reinhardt HC, Hemann MT, Hammond PT, Yaffe MB. 2020. Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. Nat Commun 11:4124. 

Krismer K, Bird MA, Varmeh S, Handly ED, Gattinger A, Bernwinkler T, Anderson DA, Heinzel A, Joughin BA, Kong YW, Cannell IG, Yaffe MB. 2020. Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression. Cell Reports 32.

Lam FC, Kong YW, Huang Q, Vu Han T-L, Maffa AD, Kasper EM, Yaffe MB. 2020. BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage. Nat Commun 11:4083.

Lam FC, Kong YW, Yaffe MB. 2020. Inducing DNA damage through R-loops to kill cancer cells. Mol Cellular Oncology.

Lau AN, Li Z, Danai LV, Westermark AM, Darnell AM, Ferreira R, Gocheva V, Sivanand S, Lien EC, Sapp KM, Mayers JR, Biffi G, Chin CR, Davidson SM, Tuveson DA, Jacks T, Matheson NJ, Yilmaz O, Vander Heiden MG. 2020. Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma. eLife 9:e56782.

Lau AN, Vander Heiden MG. 2020. Metabolism in the tumor microenvironment. Annual Review of Cancer Biology 4: 17–40.

Lim DC, Joukov V, Rettenmaier TJ, Kumagai A, Dunphy WG, Wells JA, Yaffe MB. 2020. Redox priming promotes Aurora A activation during mitosis. Sci Signal 13.

Liu VM, Howell AJ, Hosios AM, Li Z, Israelsen WJ, Vander Heiden MG. 2020. Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity. FEBS Letters 594:646-664.

Liu Y, Shi N, Regev A, He S, Hemann MT. 2020. Integrated regulatory models for inference of subtype-specific susceptibilities in glioblastoma. Mol Syst Biol 16:e9506.

Morshed N, Ralvenius WT, Nott A, Watson LA, Rodriguez FH, Akay LA, Joughin BA, Pao P-C, Penney J, LaRocque L, Mastroeni D, Tsai L-H, White FM. 2020. Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration. Mol Syst Biol 16:e9819.

Mu L, Kang JH, Olcum S, Payer KR, Calistri NL, Kimmerling RJ, Manalis SR, Miettinen TP. 2020. Mass measurements during lymphocytic leukemia cell polyploidization decouple cell cycle- and cell size-dependent growth. PNAS June 24. 

Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, Rajasekhar VK, Kastenhuber ER, Bacha S, Sriram RK, Stein BD, Bakhoum SF, Snuderl M, Cotzia P, Healey JH, Mainolfi N, Suri V, Friedman A, Manfredi M, Sabatini DM, Jones DR, Yu M, Zhao JJ, Jain RK, Keshari KR, Davies MA, Vander Heiden MG, Hernando E, Mann M, Cantley LC, Pacold ME. 2020. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer Discov.

Quinnell SP, Leifer BS, Nestor ST, Tan K, Sheehy DF, Ceo L, Doyle SK, Koehler AN, Vegas AJ. 2020. A Small-Molecule Inhibitor to the Cytokine Interleukin-4. ACS Chem Biol

Raman R, Rousseau EB, Wade M, Tong A, Cotler MJ, Kuang J, Lugo AA, Zhang E, Graybiel AM, White FM, Langer R, Cima MJ. 2020. Platform for micro-invasive membrane-free biochemical sampling of brain interstitial fluid. Science Advances 6:eabb0657.

Richters A, Doyle SK, Freeman DB, Lee C, Leifer BS, Jagannathan S, Kabinger F, Koren JV, Struntz NB, Urgiles J, Stagg RA, Curtin BH, Chatterjee D, Mathea S, Mikochik PJ, Hopkins TD, Gao H, Branch J, Xin H, Westover L, Bignan GC, Rupnow BA, Karlin KL, Olson CM, Westbrook TF, Vacca J, Wilfong CM, Trotter BW, Saffran DC, Bischofberger N, Knapp S, Russo JW, Hickson I, Bischoff JR, Gottardis MM, Balk SP, Lin CY, Pop MS, Koehler AN. 2020. Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors. Cell Chem Biol. 

Shaaya M, Fauser J, Zhurikhina A, Conage-Pough JE, Huyot V, Brennan M, Flower CT, Matsche J, Khan S, Natarajan V, Rehman J, Kota P, White FM, Tsygankov D, Karginov AV. 2020. Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity. Elife 9:e60647.

Sivanand S, Vander Heiden MG. 2020. Emerging roles for branched-chain amino acid metabolism in cancer. Cancer Cell 37, 147-156.

Sivanand S, Vander Heiden MG. 2020. Transcriptional activation of macropinocytosis by the Hippo pathway following nutrient limitation. Genes Dev 34:1253–1255.

Stopfer LE, Mesfin JM, Joughin BA, Lauffenburger DA, White FM. 2020. Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition. Nat Commun 11:2760. 

van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. 2020. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metabolism 32:391-403.e6.

Vassel F-M, Bian K, Walker GC, Hemann MT. 2020. Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer. Proc Natl Acad Sci U S A.


Babic A, Rosenthal MH, Bamlet WR, Takahashi N, Sugimoto M, Danai LV, Morales-Oyarvide V, Khalaf N, Dunne RF, Brais LK,Welch MW, Zellers CL, Dennis C, Rifai N, Prado CM, Caan B, Sundaresan TK, Meyerhardt JA, Kulke MH, Clish CB, Ng K, Vander Heiden MG, Petersen GM, Wolpin BM. 2019. Post diagnosis loss of skeletal muscle, but not adipose tissue, is associated with shorter survival of patients with advanced pancreatic cancer. Cancer Epidemiol Biomarkers Prev 28: 2062-2069.

Barrett CD, Moore HB, Kong Y, Chapman MP, Sriram G, Lim D, Moore EE, Yaffe MB. 2019. Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator–dependent manner. Journal of Trauma and Acute Care Surgery 86: 101–107.

Chen J-K, Yaffe MB. 2019. Atlas Drugged. Cell 177: 803–805.

Dalin S, Sullivan MR, Lau AN, Grauman-Boss B, Mueller HS, Kreidl E, Fenoglio S, Luengo A, Lees JA, Heiden MG, Lauffenburger DA, Hemann MT. 2019. Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance. Cancer Res 79: 5723-5733.

Diehl FF, Lewis CA, Fiske BP, Vander Heiden MG. 2019. Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation. Nat Metab 1: 861–867.

Dittmann A, Kennedy NJ, Soltero NL, Morshed N, Mana MD, Yilmaz ÖH, Davis RJ, White FM. 2019. High‐fat diet in a mouse insulin‐resistant model induces widespread rewiring of the phosphotyrosine signaling network. Molecular Systems Biology 15 (8):e8849.

Jaeger AM, Stopfer L, Lee S, Gaglia G, Sandel D, Santagata S, Lin NU, Trepel JB, White FM, Jacks T, Lindquist S, Whitesell L. 2019. Rebalancing protein homeostasis enhances tumor antigen presentation. Clin Cancer Res 25: 6392-6405.

Li L, Ng SR, Colón CI, Drapkin BJ, Hsu PP, Li Z, Nabel CS, Lewis CA, Romero R, Mercer KL, et al. 2019. Identification of DHODH as a therapeutic target in small cell lung cancer. Science Translational Medicine 11

Lien EC, Vander Heiden MG. 2019. A framework for examining how diet impacts tumour metabolism. Nat Rev Cancer 19: 651-661.

Liu VM, Howell AJ, Hosios AM, Li Z, Israelsen WJ, Heiden MGV. 2019. Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity. FEBS Letters 594: 646-664.

Lossos C, Liu Y, Kolb KE, Christie AL, Scoyk A van, Prakadan SM, Shigemori K, Stevenson KE, Morrow S, Plana OD, Fraser C, Jones KL, Liu H, Pallasch CP, Modiste R, Nguyen QD, Craig JW, Morgan EA, Vega F, Aster JC, Sarosiek KA, Shalek AK, Hemann MT, Weinstock DM. 2019. Mechanisms of lymphoma clearance induced by high-dose alkylating agents. Cancer Discov 9(7):944-961

Luengo A, Abbott KL, Davidson SM, Hosios AM, Faubert B, Chan SH, Freinkman E, Zacharias LG, Mathews TP, Clish CB, et al. 2019. Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer. Nat Commun 10: 5604.

Mattaini KR, Sullivan MR, Lau AN, Fiske BP, Bronson RT, Vander Heiden MG. 2019. Increased PHGDH expression promotes aberrant melanin accumulation. BMC Cancer 19: 723.

Miller CJ, Lou HJ, Simpson C, Kooij B van de, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, et al. 2019. Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output. PLOS Biology 17: e2006540.

Patterson JC, Joughin BA, Kooij B van de, Lim DC, Lauffenburger DA, Yaffe MB. 2019. ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest. Cell System (2):163.

Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, Varmeh S, Chen S, Balk SP, Steinmetz MO, Lauffenburger DA, Yaffe MB. 2019. VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells. Cell Systems 9 (1):74.

Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR, Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB. 2019. Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes. Cancer Res 79 (8):1952.

Schwill M, Tamaskovic R, Gajadhar AS, Kast F, White FM, Plückthun A. 2019. Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer. Sci Signal 12 (565): eaau2875.

Struntz NB, Chen A, Deutzmann A, Wilson RM, Stefan E, Evans HL, Ramirez MA, Liang T, Caballero F, Wildschut MHE, Neel DV, Freeman DB, Pop MS, McConkey M, Muller S, Curtin BH, Tseng H, Frombach KR, Butty VL, Levine SS, Feau C, Elmiligy S, Hong JA, Lewis TA, Vetere A, Clemons PA, Malstrom SE, Ebert BL, Lin CY, Felsher DW, Koehler AN. 2019. Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription. Cell Chemical Biology 26 (5):711.

Sullivan MR, Danai LV, Lewis CA, Chan SH, Gui DY, Kunchok T, Dennstedt EA, Vander Heiden MG, Muir A. 2019. Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability. eLife 8: e44235.

Sullivan MR, Mattaini KR, Dennstedt EA, Nguyen AA, Sivanand S, Reilly MF, Meeth K, Muir A, Darnell AM, Bosenberg MW, et al. 2019. Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting. Cell Metabolism (19) 30125-1.

Sullivan MR, Vander Heiden MG. 2019. Determinants of nutrient limitation in cancer. Critical Reviews in Biochemistry and Molecular Biology 54 (3): 193–207.

van de Kooij B, Creixell P, van Vlimmeren A, Joughin BA, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, et al. 2019. Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs eds. M.C. Frame and J.A. Cooper. eLife 8: e44635.

Wojtaszek JL, Chatterjee N, Najeeb J, Ramos A, Lee M, Bian K, Xue JY, Fenton BA, Park H, Li D, et al. 2019. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. Cell 178: 152-159.

Yaffe MB. 2019. Why geneticists stole cancer research even though cancer is primarily a signaling disease. Sci Signal 12 (565): eaaw3483.



Barrett CD, Hsu AT, Ellson CD, Y.Miyazawa B, Kong Y-W, Greenwood JD, Dhara S, Neal MD, Sperry JL, Park MS, et al. 2018. Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy. Clinical & Experimental Immunology 194: 103.

Creixell P, Pandey JP, Palmeri A, Bhattacharyya M, Creixell M, Ranganathan R, Pincus D, Yaffe MB. 2018. Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity. Cell Systems 7 (4): 371.

Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, et al. 2018. Altered exocrine function can drive adipose wasting in early pancreatic cancer. Nature 558 (7711):600.

Dexter JP, Ward PS, Dasgupta T, Hosios AM, Gunawardena J, Heiden MGV. 2018. Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate. J Biol Chem. 293 (52): 20051.

Hillis AL, Lau AN, Devoe CX, Dayton TL, Danai LV, Di Vizio D, Vander Heiden MG. 2018. PKM2 is not required for pancreatic ductal adenocarcinoma. Cancer & Metabolism 6: 17.

Lam FC, Morton SW, Wyckoff J, Vu Han T-L, Hwang MK, Maffa A, Balkanska-Sinclair E, Yaffe MB, Floyd SR, Hammond PT. 2018. Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Nature Communications 9 (1):1991.

Leifer BS, Doyle SK, Richters A, Evans HL, Koehler AN. 2018. Chapter Nine - An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives. In Methods in Enzymology (ed. C.A. Lesburg), Vol. 610 of Modern Approaches in Drug Discovery, pp. 191–218.

Muir A, Danai LV, Heiden MGV. 2018. Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies. Disease Models & Mechanisms 11 (8): dmm035758.

Muir A, Vander Heiden MG. 2018. The nutrient environment affects therapy. Science 360: 962–963.

Rothenberg DA, Taliaferro JM, Huber SM, Begley TJ, Dedon PC, White FM. 2018. A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth. iScience 9: 367–381.

Suarez-Lopez L, Sriram G, Kong YW, Morandell S, Merrick KA, Hernandez Y, Haigis KM, Yaffe MB. 2018. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. PNAS 115 (18):e4236.

Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG. 2018. Aspartate is an endogenous metabolic limitation for tumour growth. Nature Cell Biology 20 (7):782.

Vandekeere S, Dubois C, Kalucka J, Sullivan MR, García-Caballero M, Goveia J, Chen R, Diehl FF, Bar-Lev L, Souffreau J, Pircher A, Kumar S, Vinckier S, Hirabayashi Y, Furuya S, Schoonjans L, Eelen G, Ghesquière B, Keshet E, Li X, Vander Heiden MG, Dewerchin M, Carmeliet P. 2018. Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. Cell Metabolism 28:573-587.e13.