Making Sense of Cell Fate

July 27, 2023

Read coverage by MIT News

Yaffe Elected to American Surgical Association 

May 16, 2023

Read coverage by Koch Institute

Spranger Lab demonstrates lymph node microenvironment

suppresses anti-tumor T cells in the lung

February 2, 2023 |  Immunity 

Read coverage by MIT News

Yaffe lab creates atlas of protein kinases 

January 11, 2023 |  Nature

Read coverage by MIT News



The Spranger lab joins CPCM! 


Work from the Vander Heiden lab provides a mechanistic explanation for why hypoxic cancer cells depend on imported lipids for growth

June 23, 2022  |  Nature Metabolism

Read coverage by Columbia University Irving Medical CenterBioSpace

Congratulations to CPCM members Mike Yaffe and Michael Hemann on winning a 2022 Bose grant for ambitious ideas!

June 17, 2022  

Read coverage by MIT News

CPCM-member Forest White collaborated with KI colleague Tyler Jacks on deciphering the immunopeptidome in vivo to reveal new tumor antigens

June 15, 2022  

Manalis Lab study finds that cells take out the trash before they divide

May 10, 2022  |  eLife

Read coverage by MIT News

White Lab postdoc and Convergence Scholar Tigist Tamir creates "Edges and Nodes," a video series aimed at demystifying the life of a scientist 

March 2022  

Explore more



Congratulations to Jason Conage-Pough (White lab) and Alicia Darnell (Vander Heiden lab) on receiving the 2021 Peter Karches Mentorship Prize!

November 5, 2021

Yaffe lab research, in collaboration with the Irvine lab, finds that combining chemotherapy, tumor injury, and immunotherapy can re-engage the immune system to destroy tumors in mice

October 19, 2021  |  Science Signaling

Read coverage by MIT News

CPCM member Angela Koehler participates in AACR discussion panel on the importance of academia-industry collaboration, "Embracing Entrepreneurship in Cancer Research"

May 20, 2021

Congratulations to CPCM member Matthew Vander Heiden upon being selected as the new Director of MIT's Koch Institute for Integrative Cancer Research

April 1, 2021

Read coverage by MIT News, Boston Globe, Boston Business Journal, Endpoints News

Research from the Vander Heiden lab highlights the role of fatty acid synthesis in breast cancer cells that have spread to the brain, potentially leading to new treatment strategies

April 1, 2021  |  Nature Cancer

Read coverage by Mass General News

Research in the Yaffe lab is supporting positive clinical trial data toward better treatment response predictions in prostate cancer

March 11, 2021

Read coverage by KI News

Congratulations to CPCM Director Michael Yaffe upon being named a 2021 MIT MacVicar Faculty Fellow, in recognition of his exemplary and sustained contributions to undergraduate education at MIT!

March 11, 2021

Yaffe Lab finds that MAPKAP kinase-2 drives expression of angiogenic factors by tumor-associated macrophages in a model of inflammattion-induced colon cancer

Feburary 23, 2021  |  Frontiers in Immunology

A new mass spectrometry method developed in the White Lab opens up new clinical avenues for personalized treatment based on cell signaling

January 28, 2021  |  Cancer Research

Read coverage by KI News

Vander Heiden Lab study sheds light on the longstanding question of why cancer cells get their energy from fermentation

January 15, 2021  |  Molecular Cell

Read coverage by MIT News



Koehler Lab identifies a molecule that could target advanced prostate cancer as well as a variety of other cancers 

November 19, 2020  |  Cell Chemical Biology

Read coverage by MIT News

Hemann Lab establishes that two treatment methods enhance chemotherapy by the same means: cellular senescence (Study 1; Study 2)

November 17, 2020  |  PNAS

Read coverage by MIT Biology News

Michael Hemann presents "New Mechanisms for Old Cancer Drugs" as part of the Dana-Farber/Harvard Cancer seminar series

October 1, 2020

The Hemann lab's inTRINSIC model investigates subtype-specific susceptibilities in glioblastoma

September 16, 2020 | Molecular Systems Biology

The Yaffe Lab presents Transite, a computational approach to identifying RNA-binding proteins 

August 25, 2020 | Cell Reports

Read coverage by KI News

The Yaffe Lab and colleagues describe the concept of augmented synthetic lethality which can enhance chemotherapy response 

August 17, 2020 | Nature Communications

Read coverage by KI News

Yaffe Lab research shows that BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage

August 14, 2020  |  Nature Communications

Read coverage by KI News, Author's view

Allison Lau and colleagues in the Vander Heiden Lab dissect cell type-specific metabolism in pancreatic ductal adenocarcinoma

July 10, 2020 | eLife

Read coverage by Science in Boston

Angela Koehler's Kronos Bio reports positive results in preclinical study of investigational CDK9 inhibitor

July 9, 2020

Manalis lab monitors cell growth efficiency by studying cell size and cell cycle

June 24, 2020 | PNAS

Lauren Stopfer and colleagues from the White and Lauffenburger labs are counting antigens

June 2, 2020 | Nature Communications

Read coverage by MIT News and KI News

Congratulations to Lauren Stopfer (White lab) and Suzy Ramos (Hemann lab) on receiving a 2020 Margaret A. Cunningham Immune Mechanisms in Cancer Research Fellowship Award

April 2020


CPCM research, industry, and patients: Coming full circle

March 23, 2020

Read coverage by MIT News

Hemann lab’s Sarna Jeewajee brings along music while studying cancer

February 2, 2020




Matt Vander Heiden in the Spotlight: Understanding cancer metabolism

December 4, 2019


Congratulations to Rob Wilson (Koehler lab) on receiving the 2019 Peter Karches Mentorship Prize!

November 15, 2019


Vander Heiden and Jacks labs join forces to identify a new therapeutic target for small cell lung cancer

November 6, 2019 | Science Translational Medicine

Read coverage by MIT News and on the NIH Director's blog

Congratulations to Lauren Stopfer (White lab) on her 2020 Siebel Scholar Award for academic achievement and leadership!

September 25, 2019

Read coverage by MIT News

Yaffe lab identifies a new drug combination to kill cancer cells

July 10, 2019 | Cell Systems

Read coverage by MIT News

Hemann lab and collaborators discovered a compound that makes cancer cells more susceptible to chemotherapy

June 6, 2019 | Cell 

Read coverage by MIT News and KI News

New study from the Vander Heiden lab on the role of serine availability in tumor growth

June 4, 2019 | Cell Metabolism

Congratulations to CPCM member Angela Koehler for receiving the NSF Career Award! 

May 1, 2019 

Vander Heiden lab and colleagues develop a new method to measure tumor nutrient availability in mice

April 16, 2019 | Elife

Read more: MIT News, KI News and The Atlantic

Koehler lab reports a novel small molecule that attenuates Myc-driven transcription

March 14, 2019 | Cell Chemical Biology

Read coverage by MIT News and KI News

Angela Koehler receives the MIT Junior Bose Award for Teaching Excellence

March 2019

New Yaffe lab study on ROS and oxidative stress in cancer cells  

February 20,  2019  | Cell Systems

The Manalis lab joins CPCM! 


An insightful essay by CPCM Director Michael Yaffe in Science Signaling

January 22, 2019 | Science Signaling

Read coverage by KI News



Learn more about the Koehler lab array-based ligand discovery platform

2018  | Methods in Enzymology

Congratulations to Shanarya Sivanand (Vander Heiden lab) on receiving a postdoctoral fellowship from the Damon Runyon Cancer Research Foundation!

White lab paper just accepted: "A proteomics approach to profiling the temporal translational response to stress and growth"

November 1,  2018  | iScience

New study from the Vander Heiden lab on isocitrate dehydrogenase and 2-hydroxyglutarate production

October 30,  2018  | Journal of Biological Chemistry

Congratulations to Shelby Doyle (Koehler lab graduate student) on receiving the 2018 Peter Karches Mentorship Prize!

October 29,  2018  

The Vander Heiden lab explores the role of PKM2 in pancreatic cancer

October 23,  2018  | Cancer & Metabolism

CPCM faculty member Angela Koehler reflects on Kendal Square's rise

October 18,  2018  | MIT Spectrum

Discovery of synergistic combination therapy heads to a clinical trial

October 3,  2018  

Meet the 2019 class of Convergence Scholars

November 7, 2018

Read coverage by KI News

Congratulations to Allison Lau (Vander Heiden lab postdoc) on receiving the Koch Institute Stanley (1958) and Bonnie Klein Research Travel Fellowship!


New publication from the Yaffe lab in Cell Systems

September 19,  2018  | Cell Systems

Read more about this work: Cell Systems PreviewKI news.

Congratulations to Azucena (Susy) Ramos (Hemann lab MD/PhD student) for receiving the prestigious Ruth L. Kirschstein Award (F31) from the NIH! 


Great article about CPCM member Matt Vander Heiden

August 28, 2018 | MIT News

Congratulations to Tatiana Netterfield (Yaffe lab grad student) on being awarded the NSF Graduate Research Fellowship!


Read more about the 2018 NSF GRFP awardees here

Another informative review from the Vander Heiden lab on cancer cell metabolism

August 7, 2018 | Disease Models & Mechanisms

New study from the Vander Heiden lab on the role of aspartate in cancer

June 25, 2018 | Nature Cell Biology

Read coverage by MIT News and Nature News & Views.

Vander Heiden lab and clinical collaborators identify a mechanism for tissue wasting in pancreatic cancer

June 20, 2018 | Nature

Read more about this work: MIT News, Nature News & Views, STAT News

Great perspective from the Vander Heiden lab on how the nutrient environment affects cancer therapy

June 1, 2018 | Science

Yaffe/ Floyd/ Hammond lab collaboration: using targeted nanoparticles to fight brain tumors

May 18, 2018 | Nature Communications 

Read coverage by MIT News and Nature Nanotechnology News & Views

Nick Struntz (Koehler lab postdoc) awarded MIT-GSK Gertrude B. Elion Fellowship

April 17, 2018 | MIT News

New study from the Yaffe Lab offers novel insight into colon cancer development

April 16, 2018 | PNAS

The Man Who Uncovered a New (Old) Way to Fight Cancer

February 21, 2018 | MIT Technology Review

Fine-tuning cancer medicine

February 1, 2018 | MIT News